Fenben lab fenbendazole belongs to the family of benzimidazole carbamate anthelmintics that have been in use as veterinary and human anthelmintics for nearly six decades. These anthelmintics have broad-spectrum efficacy, with activity against many roundworm species, including most types of tapeworms. This medication does not alter the organic functioning of the host but instead kills parasites by binding to b-tubulin and disrupting microtubule function, resulting in the death of the parasite cell.
It is a moderate-acting drug that should take effect within a few days of administration. However, it may take a few weeks for the effects to be realized in the body of an affected pet. It is important to give this medication at the correct time, as failure to do so can result in an increase in the duration of treatment required. This medication should not be given to pets in the early stages of growth or during molting, as it can damage new feathers.
Fenbendazole is absorbed primarily through the gastrointestinal tract. It is metabolized to its active methylenedioxy-substituted sulfoxide form in the liver. This process is facilitated by cytochrome p4501A. Cytochrome p4501A is the major oxidative enzyme in this organism and a major site of fenbendazole metabolism (Kohler, 2001).
The sulfoxide metabolite exerts its antiparasitic and antimalarial action by inhibiting ATP synthesis in the parasite. It also acts as a cholinesterase inhibitor, which prevents hydrolysis of acetylcholine, thereby blocking nerve transmission in the body. This results in a lack of muscle movement, as well as an inhibition of the nerves responsible for heartbeat and respiration.
This medication is also used to treat intestinal helminths in horses, cattle and camelids, as well as nematodes, cestodes, lungworms, and ticks. It is a popular choice for treating Giardia infections in dogs and cats.
A recent study showed that a combination diet of fenbendazole and vitamins suppressed tumor growth in mice that were subcutaneously flank-implanted with lymphoma cells. Tumor growth was assessed at 4-d intervals until the largest tumor reached a calculated volume of 1500 mm3. Initial complete blood counts did not differ among groups and, by study termination, both total white cell and neutrophil counts were significantly (P = 0.001 and P = 0.04, respectively) lower in the group receiving the vitamin-plus-fenbendazole diet compared to controls. fenben lab fenbendazol